Cast and Crew :
 Julia Roberts as Charlotte the Spider (voice)
 Steve Buscemi as Templeton the Rat (voice)
 John Cleese as Samuel the Sheep (voice)
 Oprah Winfrey as Gussy the Goose (voice)
 Cedric the Entertainer as Golly the Goose (voice)
 Reba McEntire as Betsy the Cow (voice)
 Kathy Bates as Bitsy the Cow (voice)
 Robert Redford as Ike the Horse (voice)
 Thomas Haden Church as Brooks the Crow (voice)
 André Benjamin as Elwyn the Crow (voice)
 Dominic Scott Kay as Wilbur (voice)
 Sam Shepard as Narrator (voice)
 Abraham Benrubi as Uncle the Pig (voice)
 Dakota Fanning as Fern Arable
 Kevin Anderson as Mr. Arable
 Essie Davis as Mrs. Arable
 Siobhan Fallon Hogan as Mrs. Zuckerman
 Gary Basaraba as Homer Zuckerman
 Beau Bridges as Dr. Dorian
 Brian Stepanek as Sheep Group (voice)
Louis Corbett as Avery | Robyn Arthur as Teacher | Julian O'Donnell as Henry Fussy | Nate Mooney as Lurvy | Nicholas Bell as Minister | Teague Rook as Well Dressed Man | Julia Zemiro as Bystander | Denise Kirby as New Teacher | Robert Plazek as Ball Thrower | Joseph Lotesto as Young Boy | Michael Roland as Mayor | Don Bridges as Announcer | Ian Watkin as Fair Official | Joel McCrary as Sheep Group (voice) | Fred Tatasciore as Sheep Group (voice) | Bradley White as Sheep Group (voice) | Maia Kirkpatrick as Joy the Baby Spider (voice) | Jennessa Rose as Aranea the Baby Spider (voice) | Briana Hodge as Nellie the Baby Spider (voice) | Dale Azzopardi as Photographer (uncredited) | Geoff Burgess as Photographer (uncredited) | Ella Scott Lynch as Girl at Fair (uncredited) | Greg Marian as Farmer (uncredited) | Stefano Mazzeo as Fair Member (uncredited) | Elizabeth Saunders as Girl at Fair (uncredited) | Executive Producer : Julia Pistor | Producer : Jordan Kerner | Director : Gary Winick | | 